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Recently, an increase in BDNF synthesis has been demonstrated in a pentylenetetrazol (PTZ) kindling model of epilepsy, after chronic treatment with liraglutide in combination with antiepileptic drug, levetiracetam, which also exerted antidepressive effects, e.g
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This increases the concentration of malonyl-CoA, the first intermediate in fatty acid synthesis, leading to the inhibition of carnitine acyltransferase 1, thereby preventing fatty acid entry into the mitochondrial matrix for oxidation
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