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Patients should contact their GP or diabetes specialist nurse if they experience: Red flag symptoms requiring urgent assessment: Severe, persistent abdominal pain , particularly if localised or accompanied by fever, which could indicate pancreatitis (a rare but serious adverse effect of GLP-1 receptor agonists)
B12 deficiency was among the nutrients of concern, alongside iron, calcium, magnesium, and vitamins D and K
10.1016/S0140-6736(21)02188-7 39 DelghandiM
The added GIP pathway enhances appetite suppression, insulin secretion, and fat metabolism beyond what GLP-1 alone provides, which explains tirzepatide's higher average weight loss across clinical trials
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