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Vitamin b12 needs those enzymes and intrinsic factor to get absorbed in gut
Clements RS et al
However, very high doses may cause side effects such as: B12 can also interact with certain medications, including those used to treat acid reflux, such as Prilosec (omeprazole) and Prevacid (lansoprazole), as well as some diabetes medications, such as metformin
Red blood cell production B12 is required to form healthy red blood cells
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