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We review history, medications, and labs to confirm safety and candidacy

This is crucial for safely prescribing powerful medications like semaglutide and tirzepatide

Image Credit: Love Employee / Shutterstock In a recent study published in the International Journal of Obesity , researchers assessed the effects of glucagon-like peptide 1 (GLP-1) receptor agonists (RAs) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonists on weight and body composition in adults with overweight or obesity

Key Takeaways: Semaglutide and Fatigue Fatigue affects approximately 10% to 15% of people taking semaglutide Usually temporary, most common during first few weeks and dose increases Primarily caused by reduced calorie intake and rapid metabolic changes, not the medication directly Often improves within 2 to 4 weeks as your body adapts to each dose Manageable through proper nutrition, hydration, sleep, and activity strategies Persistent severe fatigue warrants medical evaluation Different from dangerous fatigue that signals medical problems Most people maintain normal energy levels throughout treatment Understanding Why Semaglutide Can Cause Tiredness Before jumping to solutions, understanding the mechanisms behind semaglutide-related fatigue helps you address the root causes effectively

The agency does not have information on whether these salts share the same chemical and pharmacologic properties