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In the STEP-1 trial of 1,961 adults (Wilding and colleagues, Once-Weekly Semaglutide in Adults with Overweight or Obesity, New England Journal of Medicine, 2021), participants on semaglutide 2.4 mg lost an average of 14.9 percent of their body weight at 68 weeks, compared to 2.4 percent on placebo

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DAC vs No DAC: The Main Pharmacokinetic Difference The simplest way to understand DAC is as a duration modifier: with DAC: albumin association produces prolonged exposure measured in days