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Qsymia comes closest but still falls slightly short of GLP-1 results

GLP-1RAs stimulate insulin secretion and suppress glucagon secretion, which may modify cardiac energy metabolism in T2DM patients [103]

Uncommon and rare adverse effects include cystitis, folliculitis, gastrointestinal infections, hypersensitivity reactions, changes in appetite, depression, insomnia, balance disorders, lethargy, restless leg syndrome, syncope, photophobia, presbyopia, tinnitus, confusion, palpitations, hypertension, hypercholesterolaemia, and weight gain

3-5 g/day) are effective for increasing intramuscular creatine stores, muscle accretion and muscle performance/recovery. Its also unnecessary to cycle off creatine because your body wont build up tolerance to it

Retatrutide is currently in Phase 3 clinical development