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J Infect Dis

Pregnant or breastfeeding women should not use AOD-9604 due to lack of safety data in these populations

The choice between bacteriostatic water vs sterile solution or water depends on safety, shelf life, and clinical guidance

In the first year following diagnosis, we found increased cumulative incidence risk ratios in a number of outcomes including: - Any mental, behavioural, or neurodevelopmental disorder 1.96 (1.93 - 1.99) - Postpartum depression 2.70 (2.61 - 2.79) - Eating disorders 2.06 (1.85 - 2.89) - PTSD 1.77 (1.69 - 1.86) We also saw significantly increased risk in rare but serious outcomes such as: - Wernicke's encephalopathy 2.39 (1.25 - 4.56) - Puerperal psychosis 1.80 (1.48 - 2.20) Interestingly, cases of hyperemesis gravidarum with metabolic disturbance displayed a significantly lower risk of any depression and postpartum depression compared with those without metabolic disturbance

It can be sterile water (no preservative, single use) or bacteriostatic water (with preservative, multi-dose), so not all reconstitution water is bacteriostatic.