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It is naturally present in human blood, saliva, urine, and its plasma concentration declines with age from approximately 200 ng/mL at age 20 to under 80 ng/mL after age 60

After that, the dose increases to 1 mg weekly for four weeks, then to 1.7 mg weekly for another four weeks, before reaching the maintenance dose of 2.4 mg weekly

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It works by binding to the ghrelin receptor (GHS-R1a) in the hypothalamus and pituitary, triggering a calcium/PKC signaling cascade that releases stored growth hormone, while separately blunting somatostatin's inhibitory signal

European Journal of Anatomy