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Baseline body weight, insulin resistance severity, and beta-cell function all contribute to treatment response
Zhang Q, Delessa CT, Augustin R, et al
Our findings indicate that FOXO4-DRI promotes apoptosis in senescent cells by disrupting the FOXO4-P53 interaction, thereby releasing and phosphorylating P53, which then translocates to the cytoplasm
doi: 10.1016/j.bbi.2021.05.013 149 WeickertTWJiEGalletlyCBoerrigterDMorishimaYBruggemannJet al
However, clinical trials revealed a significant side effect: weight loss
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