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Subjects were dosed with each test article following a randomized, cross over study design across two study phases, separated by a 4-6 week washout duration
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Some patients remain at lower doses (2.5 mg or 5 mg) due to gastrointestinal side effects or insurance restrictions, never reaching the 10 mg or 15 mg doses where maximal efficacy was demonstrated in clinical trials
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The liver can release extra sugar into the blood as needed
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