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CJC-1295 without DAC (Drug Affinity Complex) combined with Ipamorelin acts as a GHRH analog and GHRP-6 receptor agonist respectively, stimulating the pituitary to release growth hormone in pulsatile bursts that mirror natural circadian rhythms

Tesamorelin is a GHRH analog that stimulates pituitary release of growth hormone, driving lipolysis specifically in visceral adipose tissue

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and for those tesamorelin-treated patients completing the 26-week treatment period that were re-randomized to tesamorelin (T-T group) or re-randomized to placebo, 36.6% and 32.0%, respectively, had impaired glucose tolerance, while 2.0% re-randomized to tesamorelin and 6.0% re-randomized to placebo had diet-controlled diabetes mellitus