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All types of substance addictions are clinically codified as substance use disorder, which is considered a chronic disease characterized by a transition from recreational drug use to compulsive and disordered use

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doi: 10.1128/jvi.01923-22 61 PolakSBVan GoolICCohenDvon der ThusenJHvan PaassenJ

It lives in and strengthens the guts mucosal lining, directly interacting with cells to naturally support endogenous GLP-1 pathways

Based on these limitations, future research should integrate detailed exposure metrics, genetic profiling, and chronotype assessments to better clarify mechanisms and identify high-risk subgroups