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For quality control, we excluded participants who (1) have excess relatedness (more than 10 putative third-degree relatives), (2) have inconsistent information about sex based on genotyping and self-report, (3) have sex-chromosomes not XX or XY, (4) have poor-quality genotyping based on heterozygosity and missing rates, or (5) have withdrawn from UK Biobank
Acetylcholine is a major neurotransmitter in the brain, promoting experience-induced neuroplasticity, the synchronization of neuronal activity, and network connectivity (38)
Figure 1 Figure 2 3 Mechanisms of action for GLP-1R agonists to control food intake GLP-1R agonists primarily act to reduce body weight by suppressing energy intake
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