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Wang D, Luo P, Wang Y, Li W, Wang C, Sun D, Zhang R, Su T, Ma X, Zeng C, Wang H, Ren J, Cao F: Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP/PKA/Rho-dependent mechanism

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The titration schedule used in clinical trials (slow, stepwise dose increases over multiple weeks) is specifically designed to minimize the intensity of these early side effects