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The "right model" is access with guardrails, qualified clinicians, licensed pharmacies, validated quality testing and "meaningful" patient follow-up, according to the expert

doi: 10.1136/bmjdrc-2020-001319 102 JieZYuXLiuYSunLChenPDingQet al

Acquisition of 1 H-NMR spectra and metabolic profiling The lyophilized metabolic extracts were suspended in 0.6 ml of deuterated water (Cambridge Isotope Laboratories Inc., Tewksbury, MA, USA) containing phosphate buffer (100 mM) and TSP (3-3-(trimethylsilyl)-2,2,3,3-tetradeuteropropionic acid or TMSP- d 4 , Cambridge Isotope Laboratories) (0.5 mM) and inserted into a 5 mm NMR tube for immediate acquisition