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Das langfristige Melanomrisiko wird zwar nach wie vor genau beobachtet, doch haben die aktuellen Daten kein dramatisches Signal ergeben, obwohl die vorbergehende Verdunkelung bestehender Nvi und das Auftreten neuer pigmentierter Lsionen hufig genug sind, um eine regelmige dermatologische Kontrolle zu rechtfertigen

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134 However, because of heterogeneity among cancer cells, other studies have shown that IDH2 expression is decreased in metastatic HCC and gastric cancer tissues compared with paired normal tissues

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