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The medications themselves are not causing weight loss
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To test the hypothesis, we applied ferroptosis inhibitor Ferrostatin-1 (Ferr-1), necrosis inhibitor Necrostatin-1 (Nec-1), or apoptosis inhibitor Z-VAD-FMK to treat VRK2-KO cells exposed to APR-017
Figure 1 In line with these observations, weight loss has emerged not only as a supportive strategy but also as a disease-modifying intervention in PsA (32)
