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Br Med J (1950) 2(4685):9058.10.1136/bmj.2.4685.908 7 LederleFA

Erdem et al., 2012 investigated homocysteine level in the patients with severe sepsis along with serum ischemia-modified albumin (IMA), malondialdehyde (MDA), folic acid and vitamin B (12), and their association with high-sensitivity C-reactive protein compared to healthy controls

Hepcidin expression in astrocytes regulates iron intake, which helps mitigate neuronal loss in the cortex and hippocampus of amyloid precursor protein/presenilin-1 (APP/PS1) mice (Xu et al., 2020

Dihexa oral capsules are typically taken once daily, often in the morning to align with natural circadian cognitive patterns, though timing can be adjusted based on individual response and therapeutic goals

Ultimately, these series of reactions will activate the apoptotic pathways 33,34 (Figure 4)