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In research models, elevated NNMT activity has been associated with: lower NAD levels, with downstream effects on mitochondrial energy production

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The key learnings are crucial, and when taken together, may be the recipe for success that every manufacturer needs: Patients are playing a greater role in their care

However, this often means taking supraphysiological doses, which may increase the risk of side effects like joint swelling and insulin resistance

At the biochemical level extreme shifts in the NADH to NAD plus ratio can alter redox balance