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Several situations warrant pausing at a dose level for additional weeks before escalating: Persistent nausea: If nausea lasts beyond 2 weeks at any dose level, stay at that dose for an additional 2 to 4 weeks

Clinical Studies 14.1 Overview of Clinical Studies RYBELSUS has been studied as monotherapy and in combination with metformin, sulfonylureas, sodium-glucose co-transporter-2 (SGLT-2) inhibitors, insulins, and thiazolidinediones in patients with type 2 diabetes mellitus

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Unexplained weight loss that exceeds expected targets or is accompanied by other concerning symptoms

Recognize symptoms early and seek care promptly if severe or persistent