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While antioxidant systems can mitigate oxidative injury to healthy tissues during breast cancer treatment, indiscriminate use of exogenous antioxidant supplements during ROS-dependent therapies such as anthracycline chemotherapy and radiotherapy may theoretically reduce treatment efficacy by protecting malignant cells from oxidative damage

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[12] [13] The United States Food and Drug Administration has indicated a black box warning given the frequency and severity of the side effects and teratogenicity