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An independent external event adjudication committee reviewed cardiovascular events, acute pancreatitis, and deaths

Sirtuins, particularly SIRT1 and SIRT3, have been extensively studied for their roles in metabolic health

The SELECT trial, published in the New England Journal of Medicine , found that semaglutide, known by the brand name Ozempic, significantly reduced the risk of heart attacks and strokes in people with obesity and established cardiovascular disease

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