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Evidence suggests that DPP-4 inhibitors reduce urinary albumin excretion, oxidative stress, and renal dysfunction in patients with T2D independent of their glucose-regulatory activity [117, 118]
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In the future, further insights into this question may be gained by identification of additional proteins with specific roles in GLP-1R sorting along the endocytic pathway as targets for genetic manipulation
The FDA ordered sales of compounded GLP-1s to stop last spring when brand-name drugs were no longer in shortage, though some compounding pharmacies have continued operations using formulations that may fall into regulatory gray areas, according to the Times
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