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10.3390/ijms21134777 Int J Mol Sci

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Higher mitochondrial metabolism in the neurons result in generation of Complex I dependent hydrogen peroxide and neuronal membranes, rich in polyunsaturated fatty acids, are particularly vulnerable to oxidative stress due to their possession of unsaturated double bonds

Another consideration is that some individuals with histamine issues or sulfur sensitivities may not tolerate glutathione well because it contains additional sulfur, beyond the sulfur that is contained within the amino acid cysteine