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The anti-inflammatory actions of GCs are mediated through transrepression , a process in which the ligand-activated GR, often as a monomer, interacts with and inhibits the activity of pro-inflammatory transcription factors, such as nuclear factor-kappa B (NF-B) and activator protein-1 [23]
Clin Endocrinol (Oxf)
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About 27% were consistently adherent in year one (meaning they took the drug regularly), which fell to 17% in year two
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