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The research was carried out in the laboratory of Stephen Bloom (figure 30), an endocrinologist with a long-standing interest in glucagon as well as obesity and diabetes

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GLP-1 is mainly produced in the enteroendocrine L cells located in the distal intestine exerting its effects through binding to the GLP-1 receptors (GLP-1R) expressed in the pancreas, heart, blood vessels, gastrointestinal tract (GIT), kidney, lung, breast, and central nervous system [11],[12]