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In metabolic disorders such as type 2 diabetes (T2D), microbial dysbiosis is characterized by an increase in Gram-negative Enterobacteriaceae and a reduction in short-chain fatty acid (SCFA)-producing bacteria such as Bifidobacterium, resulting in elevated circulating LPS levels and metabolic endotoxemia (Nguyen et al., 2014)
Risk is highest during the initial titration phase and subsequent dose increases, particularly in vulnerable populations such as older adults or those with pre-existing conditions
Menurut Prof
The most common side effect is a mild stimulant effect, which is why an AM dodge is recommended
Semaglutide typically comes in two forms: a pre-filled pen or a vial with separate syringes
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