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May help support normal immune function
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Understanding how this dual engagement works at the receptor and cellular level is increasingly relevant for both clinicians and drug discovery teams designing the next generation of incretin mimetics
The antioxidant function of GSH is determined by the redox-active thiol (-SH) of cysteine that becomes oxidized when GSH reduces target molecules (Pompella et al., 2003)
Variants of OXM resistant to DPP-IV (achieved by addition of PEG [86], fatty acids [87], substitution of certain amino acids [85] or even combined modifications [88]) have been advanced to circumvent the limited clinical potential of the native peptide
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