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E N D Presentation Transcript INCRETINS Glucagon-like Peptide 1 (GLP-1)and Glucose-Dependent Insulinotrophic Polypeptide (GIP) account for ~90% of the incretin effect In response to equivalent hyperglycemic stimuli, ORAL glucose elicits a greater insulin response than IV glucose Insulin Glucose-Stimulated Secretion of Insulin Glucose GLUT2 Pancreatic Cell SUR Glucose Potassium channel GK K+ Pyruvate GLP-1 ATP + ATP GIP TCA Cycle* AC + Calcium channel cAMP [Ca2+] Amplifying Triggering AC = adenylyl cyclase

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Taking the medication exactly as prescribed can significantly improve lung function and overall quality of life

This improves AI accuracy and trust , compresses cycle times for eCTD/CMC/BMR , and cuts rework and rejection risk, crucial as GLP-1 demand grew ~ 38% annually (20222024) and compounding workarounds wound down in 2025