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The drugs can induce mitochondrial toxicity by inhibiting mtDNA replication, translation, and/or methylation, as summarized in Table 1 (Xiao et al., 2018)
The FDA also cited the company for using unvalidated laboratory testing methods that failed to detect impurities and for inadequate equipment cleaning and cleaning validation practices that increased the risk of cross-contamination between products
& Cidlowski, J
Membranes were blocked with 5% non-fat milk and incubated with mouse anti-5mC (#61480, Active motif) or anti-5hmC (#39999, Active motif) followed by a horseradish peroxidase-conjugated antibody (Santa Cruz Biotechnology)
A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress
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