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The compounds require injection, and access can be limited due to cost and shortages
Usually the discomfort is short lived and does not linger after a minute
Instead of overcoming the metabolic adaptation, higher doses frequently exacerbate side effects like nausea, fatigue, and gastrointestinal distress
The NHS treatment page lays it out clearly: Loading phase (no neurological symptoms): 1mg every other day for two weeks, or until symptoms stop improving
This is important because higher doses of vitamin B12 arent generally a problem
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