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Animals and Grouping Adult male C57BL/6 mice were purchased from the Center of Pasteur Institute (Tehran, Iran) and housed in the Tarbiat Modares University animal laboratory

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Anabolic Signaling: The released GH stimulates the liver to produce IGF-1, which activates the mTORC1 pathway in muscle (protein synthesis) and the Runx2 pathway in bone (osteoblast differentiation)

doi: 10.3892/etm.2019.7347 36 HadjiyanniISiminovitchKADanskaJSDruckerDJ

These may include: Your doctor may recommend a combination of these options to achieve safe and progressive improvements, depending on your skin profile and concerns