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Manufacturers demonstrating bioequivalence in a single Phase 3 trial (rather than the traditional two trials) can achieve interchangeable status, allowing pharmacy-level substitution without prescriber intervention

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This typically occurs after 4 to 5 weeks of regular use

Semaglutide was metabolized through proteolytic cleavage of the peptide backbone and sequential -oxidation of the fatty acid side chain

Instead, they build patent fortresses composed of multiple layers: Compound Patents : These cover the core amino acid sequence (e.g., semaglutide)