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JAMA Netw Open 7(8):e2423385 Zhou J, Huang W, Xie Y, Shen H, Liu M, Wu X (2025) Risk of ophthalmic adverse drug reactions in patients prescribed glucagon-like peptide 1 receptor agonists: a pharmacovigilance study based on the FDA adverse event reporting system database

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TNF- levels decreased by an average of 28% (p IL-6 levels decreased by an average of 24% (p The study found a 31% reduction in cartilage degradation markers (p The researchers used regression analysis to show that GLP-1 receptor activation has a strong negative relationship with inflammatory cytokine levels, which they measured at r = -0.68

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