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Its released by specialised cells in the small intestine and plays a central role in regulating blood sugar and appetite

Some patients experiencing significant weight loss may notice changes in skin texture or elasticity, but these are generally related to the weight loss itself rather than a direct medication effect

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Retatrutide's results are also not as fast-acting as methods like the protein-sparing modified fast, a medically monitored diet in which people take in around 800 calories per day, Yerevanian says