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Eli Lilly published the results of its ATTAIN-1b trial for obesity in September 2025 7 , which compared orforglipron to placebo in more than 3,100 adults without diabetes, with a BMI of 30+ or 27-30 with an obesity-related complication including hypertension, dyslipidaemia, cardiovascular disease or obstructive sleep apnoea and a history of at least one patient-reported unsuccessful dietary effort to lose body weight, who have tried unsuccessfully to lose weight with diet alone
It usually becomes noticeable around two to four months after starting treatment, and it often coincides with the period of most rapid weight loss
2025, pp
Given the regenerative potential of hMSC, understanding how GLP-1-RA affect these cells is crucial for determining further implications of these drugs on tissue homeostasis and metabolic health
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