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The immune, neurological, and endocrine systems are all impacted by chronic stress, which is linked to both hyper-and hypocortisolism (Guo et al
A., Neznamov, G
Alcohol- and other substance-use disorders may well benefit from the effects of GLP-1RAs on dopamine and opioid pathways that are dysregulated in addiction 243 , as seen in some of the studies we identified, and the same could also apply to other under-investigated disorders with similar underlying dysfunctions (for example, gambling disorder)
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