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doi: 10.1038/nri2921 94 Plsson-McDermottE

doi: 10.1002/jnr.10611 153 ChenSAnFMYinLLiuARYinDKYaoWBet al

Subjects were randomized to lixisenatide 10 mcg/d (up- or down-titrated to max 20 mcg/d) or placebo

Crohn's disease is a chronic inflammatory bowel disease (IBD) characterized by transmural inflammation that can affect any portion of the gastrointestinal tract from mouth to anus, though it most commonly involves the terminal ileum and colon

Switching to placebo at 48 hours means residual metabolic activation will be incorrectly attributed to placebo response or baseline recovery