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The GH response to secretagogues is saturable: beyond a certain point, additional GHRP-2 does not produce proportionally more GH because the pituitarys releasable pool and the receptor system are finite, and somatostatin feedback increasingly opposes release

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B.LeeB.-H.NikapitiyaC.KimJ.-H.KimT.-H.LeeH.-C.et al (2016)

The cornerstone of managing fatigue in MCAS is halting the erratic degranulation of mast cells and blocking the inflammatory mediators they release

Neuroimaging markers of energy metabolism Neuroimaging studies suggest that patients with migraine exhibit abnormal brain energy metabolism and altered functional connectivity (32)