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Moreover, GLP-1RAs induced rapid weight loss may lead to supersaturation of the bile with cholesterol and hence increased incidence of gallstones formation [3, 4]

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Por otro lado, la unin del GLP-1 con su receptor en la CBP tendra un efecto directo sobre la secrecin de insulina, potenciando las dos fases de secrecin de insulina y estimulando la transcripcin del gen y la traduccin del ARNm, incrementando as la biosntesis de proinsulina 25,26

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