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Inflammasome activation and the progression of inflammatory bowel disease are modulated by palmitoylation of NLRP3, while inflammasome activation and the severity of dextran sulfate sodium (DSS)-induced colitis in mice are effectively attenuated by pharmacological inhibition of NLRP3 palmitoylation ( Some palmitoylation-related enzymes are important regulators of IBD

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Tabanelli R, Brogi S, Calderone V

Phase 3 readouts have since pushed even higher in some populations

(FEBS Lett 1988, J Clin Invest 1993): estimulacin de sntesis de matriz extracelular en fibroblastos humanos