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Environ Toxicol Pharmacol 91:103833

Effective obesity treatment is a long-term commitment, not a one-time intervention

In addition, similar degrees of knockdown in vitro are sufficient to trigger defects in insulin secretion, suggesting that the long-term in vivo environment permits adaptive processes that are not apparent in short-term in vitro studies

long-term BPC-157 use carries unquantified risk until prospective human trials establish pharmacokinetics and toxicity thresholds across extended timeframes