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Interestingly, Pycnogenol intake in osteoarthritis patients reduced gene expression of key catabolic and inflammation markers like MMP-3, MMP-13 and IL-1 by more than 50% within knee cartilage (71)

Thiamine status should be checked at baseline and every 3 months in long-term users ALA can deplete thiamine and trigger neuropathy paradoxically resembling the deficit it was given to correct

A., Abraham, A., Roy, K., & Mukherjee, A

This is likely due to it being endogenously synthesized all throughout the body and it is basically found in all cells, sometimes in rather high concentrations

Cognitive & Mental Performance