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Chronic low-grade inflammation, however, can perpetuate tissue damage and prevent resolution

Human trials remain limited, so much of the discussion comes from preclinical research, clinician experience, and user reports

As a proof of concept, we tested this signature in previously published bulk RNA-sequencing (RNA-seq) data from in vitro OSKM reprogramming 40 , and found it was significantly enriched in iPS cells as compared to the mouse embryonic fibroblasts (MEFs) from which the iPS cells were derived (Extended Data Fig

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