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However, it must be stressed that, despite the lack of reproductive improvement, even low doses of GLP1/E were sufficient to markedly improve the metabolic perturbations in PWA mice, thus defining an optimal scenario for occasions in which the main therapeutic objective would be metabolic normalization rather than reproductive rescue, as is actually the case for most women with PCOS, without pregnancy desire, which are submitted to continued hormonal contraception plus metformin treatment
Quick answer: L-carnitine is most plausible for people with a real carnitine deficit or a context where trials show bigger effects: older adults, people with overweight or obesity, some metabolic-health populations, dialysis patients under medical care, and athletes using it for recovery over weeks, not days
Until rigorous, randomized, placebo-controlled trials are conducted and published, the responsible position is to rely on proven, evidence-based approaches to recovery and healing, and to leave unapproved peptides where they belong for now: in the laboratory, not in your body.
Symptoms associated with vitamin B12 deficiency include fatigue and lack of energy (due to anaemia), and depression, psychosis and even dementia