Accepted: Mar 25, 2020 DOI: Download citation
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Research published in neuroscience journals has shown that administration of exenatide, liraglutide, and semaglutide decreases alcohol consumption in alcohol-preferring rats and mice, with effects observed across various experimental paradigms including two-bottle choice tests and operant self-administration models
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Clinical Trial Evidence: What the Research Shows Phase 2 trial data published in the NEJM (2023) showed approximately 24% mean body weight reduction at the highest dose over 48 weeks, alongside improvements in blood pressure, lipid profiles, and fasting glucose, though Phase 3 results are still awaited