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1 Excess adipose tissue can lead to multiple obesity-related complications, including metabolic complications (e.g., type 2 diabetes, hypertension, and dyslipidemia), mechanical complications (e.g., obstructive sleep apnea and osteoarthritis), and psychological complications (e.g., depression and anxiety), with a negative effect on physical function and health-related quality of life, and reduced life expectancy

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Thats exactly why Novo Nordisk combined cagrilintide with semaglutide in CagriSemathe idea is that hitting both the amylin and GLP-1 pathways together could produce greater effects than either one alone