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In addition to its involvement in synaptic plasticity and transmission, free ARA plays a crucial role in neuroinflammation through its conversion into various eicosanoids by cyclooxygenases, prostaglandin synthases, and lipoxygenases, the activities of which have been associated with neurodegenerative diseases (Czapski et al., 2016)
Furthermore, we provide first data that the GSH level in human neurons may be mediated by NMDAR activation since the protective effect of enhanced network activity could be blocked with an NMDAR antagonist APV, consistent with the previous report (Fig
45 It has been proved that the kinases Mst1 and Mst2 detect ROS and preserve cellular redox by regulating the stability of Nrf2 in macrophages
Research Documentation Context Supports compound characterization in controlled laboratory settings
Cagrilintide and retatrutide are two investigational peptide-based medicines currently being studied for the treatment of obesity and related metabolic conditions
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