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In a Phase 1 randomized, double-blind clinical study targeting obese participants (NCT04478708), AMG133 demonstrated acceptable safety, tolerability, and significant dose-dependent weight loss
The key clinical trials discussed here are summarized in Table 2
Ethics approval and consent to participate All relevant ethics documents were approved by the Institutional Research Ethics Committee of Nanjing Medical University (for clinical patients) and Nanjing University (for mice)
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