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In this context, prioritizing treatment for high-risk groups such as individuals with advanced fibrosis, multiple cardiometabolic comorbidities, or rapid disease progression may offer the greatest clinical benefit

Given the availability of biomarkers for AD that can be used to measure brain pathology in vivo (including neuroimaging with positron emission tomography, CSF, and plasma biomarker analysis), studies are needed in older adults which measure AD biomarkers in the context of melatonin use

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